Blar i forfatter "Schröder, Katrin"

Viser treff 1-3 av 3

    • Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise 

      Hancock, Matthew; Hafstad, Anne Dragøy; Nabeebaccus, Adam A.; Catibog, Norman; Logan, Angela; Smyrnias, Ioannis; Hansen, Synne Simonsen; Lanner, Johanna; Schröder, Katrin; Murphy, Michael P.; Shah, Ajay M.; Zhang, Min (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are unclear. We identify the ROSgenerating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice. Myocardial Nox4 levels ...

    • Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival 

      Beretta, Matteo; Santos, Celio X.C.; Molenaar, Chris; Hafstad, Anne Dragøy; Miller, Chris CJ; Revazian, Aram; Betteridge, Kai; Schröder, Katrin; Streckfuß-Bömeke, Katrin; Doroshow, James H; Fleck, Roland A; Su, Tsung-Ping; Belousov, Vsevelod; Parsons, Maddy; Shah, Ajay M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-10)
      Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondrial permeability transition (mPT), which is especially important in post‐mitotic cells such as cardiomyocytes and neurons. Here, we show that stress‐induced ...

    • Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2a-mediated stress signaling 

      Santos, Celio X.C.; Hafstad, Anne Dragøy; Beretta, Matteo; Zhang, Min; Molenaar, Chris; Kopec, Jola; Fotinou, Dina; Murray, Thomas V.; Cobb, Andrew M.; Martin, Daniel; Zeh Silva, Maira; Anilkumar, Narayana; Schröder, Katrin; Shanahan, Catherine M.; Brewer, Alison C.; Brandes, Ralf P.; Blanc, Eric; Parsons, Maddy; Belousov, Vsevelod; Cammack, Richard; Hider, Robert C.; Steiner, Roberto A.; Shah, Ajay M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-07)
      Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine–threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2α phosphorylation enhances cell survival. Here, we show ...